Research hotspots and frontiers of alcohol and epilepsy: A bibliometric analysis PMC

Because of this, it’s possible that a seizure that seems to be triggered by alcohol may actually be caused by another trigger. (Lack of sleep is a common trigger for many people with epilepsy). He is 25, went out drinking with friends the night before, and binge-drank. This means consuming roughly five or more drinks for a man, or four or more drinks for a woman, in about two hours. ” This can be confusing — especially if you or someone you love has been newly diagnosed with epilepsy and is deciding whether or not to drink.

Be sure to ask your doctor about the effects of alcohol on any medications you might be taking. ” You need to consider more factors than just the alcohol itself — especially your medications. However, some medications are more likely than others to metabolize differently when alcohol is used. More recent research shows that having one to two drinks a day does not seem to affect these levels in most medications. They may slow down central nervous system responses, make a person sleepy, or cause parts of the brain to work differently. Most of these antiepileptic medications also have side effects that mimic those of alcohol.

Just as in the primary analysis, alcohol did not increase the likelihood of epileptic seizures or nonepileptic events in any of the analyses. The likelihood of epileptic seizures, nonepileptic events, and benzodiazepine rescue at any time after time zero, defined as defined as the date and time that cases first received alcohol or the equivalent hospital day and time for matched controls. Patients who censored if they were discharged before 48 hours (our cohort was already restricted to patients with at least 24 hours of follow-up after time zero, so these discharges occurred between hours 24–48 after time zero). We compared the likelihood of epileptic seizures and nonepileptic events in cases versus controls using Kaplan-Meier time-to-event analysis, as well as odds ratios for these outcomes occurring at any time during the admission.

How does alcohol dependence management impact the detoxification process and seizure risk?

  • Only a minority of patients documented details on alcohol-related seizures in seizure diaries.
  • Benzodiazepines have the most evidence for reduction in acute recurrent AWS seizures and alcohol withdrawal symptoms, either as a set protocol for higher risk patients or in a symptom-triggered fashion.
  • Additionally, prompt treatment of alcohol withdrawal seizures with benzodiazepines and antiepileptic drugs can effectively reduce the risk of seizures.
  • It should not be used in place of the advice of your physician or other qualified healthcare providers.
  • The highest risk for alcohol-related seizures is typically during detox.
  • Over the last two decades, alcohol consumption has dramatically increased in low- and middle-income countries and areas.

It should not be used in place of the advice of your physician or other qualified healthcare provider. We publish material that is researched, cited, edited and reviewed by licensed medical professionals. We are committed to helping you medically detox safely and maintain long-term sobriety. If you or a loved one are struggling with alcoholism and need help safely detoxing, we are here for you. Our program provides comprehensive follow-up care after medical detox to help maintain long-term sobriety.

Successful long-term recovery typically involves a combination of medical support, psychosocial therapies and community-based resources. Developing a tolerance for alcohol has a direct impact on the central nervous system. Alcohol acts by stimulating receptors in your brain that cause Alcohol controlled substance brain activity to be suppressed. Early intervention can dramatically reduce the risk of serious complications and set the stage for a safer, more effective recovery process.

Intake of alcohol may make the patients miss the antiepileptic drugs or reduce the efficacy of medications. Yulin Zhao and his collaborators were working on G‐protein‐gated inwardly rectifying K+ (GIRK) channels and seizures. The VOSviewer was used to color the keywords according to the average time of occurrence. The most highly cited paper (14 times) was written by Marc A. Schuckit, entitled Recognition and management of withdrawal delirium (delirium tremens).27 These findings showed that the USA and its institutions may play critical roles in the field of alcohol and epilepsy. The field of alcohol and epilepsy is booming, with increasing output.

Alcohol and seizure medication

They are caused by changes in the brain’s receptors due to prolonged alcohol exposure, which results in physical dependence and tolerance. They know more about the medications than the doctors do.” Ultimately, it’s important that you understand the side effects of your medications, as well as how they interact with alcohol, if you choose to drink. If you research a medication and these symptoms show up, it’s likely that AED will lower your tolerance for alcohol, too.

Lifestyle and home remedies

It’s well-documented that experiencing seizures during an incident of alcohol withdrawal increases the severity of the next alcohol withdrawal as well as the likelihood of experiencing another seizure or the withdrawal progressing to delirium tremens.7 The severity of alcohol withdrawal symptoms, including seizures, can be graded using the revised CIWA-Ar scale. People who have experienced seizures due to binge drinking may begin to experience unprovoked epilepsy seizures regardless of alcohol use. During alcohol withdrawal, the body’s finely tuned equilibrium is disrupted, leading to a cascade of withdrawal symptoms, including seizures. The analysis of keywords showed that epilepsy, alcohol, seizures, alcohol withdrawal, and management were the most frequently used keywords in research articles in this area.

1. Data source and retrieval strategy

This is known as an alcohol withdrawal seizure and is a serious complication that can occur when someone who has been drinking heavily for an extended period suddenly stops or reduces their alcohol intake. The longer and more frequently a person engages in binge drinking, the higher their risk of developing withdrawal symptoms, including seizures. Approximately 2–5% of those who misuse alcohol will experience alcohol withdrawal seizures. Alcohol withdrawal seizures can occur after someone has been drinking heavily for a few days or longer. This article will explain what alcohol withdrawal seizures are.. In animal studies, withdrawal symptoms and seizures have been induced after a single day or even a single dose of alcohol . Acute alcohol intoxication raises the threshold for seizures (i.e., makes seizures less likely), while alcohol withdrawal after chronic use causes a proconvulsant state 7,8.}

Take control and seize the opportunity for a healthier, seizure-free future! As our brain adjusts, we may experience mental and emotional symptoms such as anxiety, mood swings, insomnia, what is central nervous system depression confusion, and hallucinations. When we quit or cut back, alcohol’s depressant effects are reduced or eliminated and brain activity can go into overdrive. Glutamate receptors adapt to alcohol’s depressant effects by increasing brain activity to compensate. To understand why, let’s first understand why withdrawal occurs. Meanwhile, alcohol blocks glutamate receptors, decreasing brain signaling.

This is of particular concern when you’re taking certain medications that also depress the brain’s function. But as you continue to drink, you become drowsy and have less control over your actions. This may result in craving alcohol to try to restore good feelings or reduce negative ones.

The evidence for moderate alcohol use in healthy adults is still being studied. While the risk is low for moderate intake, the risk goes up as the amount you drink goes up. Thousands find freedom from alcohol every year — and so can you. “Alcohol and Seizures.” 2018. It should not be used in place of the advice of your physician or other qualified healthcare providers. Flashing lights, especially repetitive on and off or patterns, may trigger a seizure.

This study quantified scientific productions, countries, institutions, journals, authors, references, and keywords, which may help in identifying the latest progress, evolution paths, frontier research hot spots, and future research trends in this field. The location of the node indicates the time the keywords first appeared, and the lines indicate the relationships between them. We also provided the timeline view for the major clusters in Figure 8B. (B) Burst strength and time duration of the top 25 references with the strongest citation bursts. The top 100 journals, being co‐cited by at least 144 times, were used for the analysis through the VOSviewer tool. Among these journals, five of the top 10 were neurology‐related, three were alcohol‐related, and the remaining two journals were Pharmacy‐related and Multidisciplinary sciences‐related, respectively.

We compared history, treatment with benzodiazepines or antiseizure medications (ASMs), laboratory, EEG and computed tomography findings between patients with AWS relapse (r-AWS) and patients with no AWS relapse (nr-AWS). The aims of this study were to identify risk factors for AWS recurrence and to study the overall outcome of patients after AWS. Symptoms of alcohol withdrawal can include tremors, insomnia, anxiety, depression, irritability, mood swings, clammy skin, nausea, vomiting, and rapid heart rate. These medications can help manage complications of alcohol withdrawal and prevent the progression to delirium or other severe complications. The prevalence of epilepsy in alcohol-dependent patients in Western industrialised countries is at least triple that of the general population.

Even if you’re not a chronic drinker, in some cases, you may also experience withdrawal seizures after binge drinking. Binge drinking refers to a scenario where you drink a lot in a short period of time, and the seizures related to binge drinking can stem from withdrawal. If you or a loved one experiences symptoms of alcohol withdrawal—ranging from tremors, insomnia, and anxiety to seizures—reach out for professional help immediately. Alcohol withdrawal seizures pose significant health risks. Along with symptoms such as insomnia, nausea, vomiting, anxiety, and more, alcohol withdrawal can involve neurological manifestations that range in severity such as shakes, seizures, and delirium tremens.21

  • Drinking alcohol does not normally cause seizures.
  • Analysis of keywords showed epilepsy, alcohol, seizures, alcohol withdrawal, and management were common themes.
  • When you’ve been drinking heavily, suddenly stopping can make it revolt.
  • Not just the usual hangover crap, but we’re talking full-blown seizures that might land you in the hospital.
  • Alcoholism, or chronic alcohol abuse, is linked to the development of epilepsy in some individuals.
  • I’d my seizure automatically lower, or does it depend on an individual?
  • Practicing moderation, taking a more gradual approach to quitting or cutting back, and exploring supported detox options decreases our risk of alcohol withdrawal seizures.

Additionally, epilepsy medications can increase the effects of alcohol, causing each drink to make you more intoxicated than it usually would. Misusing alcohol can increase your overall risk of developing epilepsy. This can lead to temporary and lasting brain damage and increase the likelihood of seizures.

Dependence occurs when your brain has adapted to the presence of alcohol and adjusts its chemistry accordingly.17 As the alcohol wears off, those with a physical dependence can begin to feel withdrawal symptoms which may encourage them to want to drink more to lessen the effects of these symptoms.17 This can also lead to significant how long acid trip lasts cravings and compulsive drinking.17 Medications such as benzodiazepines, antiseizure drugs, and GABA-ergic medications can help prevent and treat alcohol withdrawal seizures. While small amounts of alcohol do not cause seizures, binge drinking and alcohol withdrawal can lead to status epilepticus, a life-threatening condition. While moderate drinking can have a calming effect, excessive alcohol consumption can lead to over-inhibition of the central nervous system, resulting in conditions that increase the likelihood of seizures. However, moderate to heavy alcohol use is never recommended for people with epilepsy as it can trigger seizures and increase the risk of Sudden Unexpected Death in Epilepsy (SUDEP).

Alcoholism might be more common among individuals with epilepsy, compared to the general population.31, 32, 33, 34 Alcohol, as one of the common cause inducing seizures, has garnered growing interest from researchers. It shows the evolutionary pathway in the study of alcohol and epilepsy. In this study, we conducted the first bibliometric analysis in the field of alcohol and epilepsy, which explored the hot spots and frontiers over the past 30 years and generated the corresponding knowledge maps. In this study, we conducted the first bibliometric analysis in the field of alcohol and epilepsy, which explored the hot spots and frontiers over the past 30 years and generated the corresponding knowledge maps using CiteSpace and VOSviewer. The presented study conducted the first bibliometric analysis of the field of alcohol and epilepsy, which will provide insights into the latest progress, evolution paths, frontier research hot spots, and future research trends in the field. Contact your doctor if you or someone you know is experiencing alcohol dependency or withdrawal symptoms.

Due to the retrospective design of the present study, we were not able to assess sleep quality prior to alcohol-related seizure occurrences. Furthermore, we cannot exclude hypoglycemic episodes caused by acute heavy alcohol consumption (26), which may have contributed to the manifestation of epileptic seizures (27). We addressed this by focusing only on alcohol-related seizures that had occurred within the last 12 months. Only a minority of patients documented details on alcohol-related seizures in seizure diaries. Moreover, patients were seen at our institution at scheduled outpatient visits and did not attend the clinic after acute manifestations of alcohol-related seizures.

Yes, alcohol withdrawal can cause seizures. Not everyone who quits drinking will have a seizure, but having certain risk factors can significantly increase the odds. So, can you get seizures from alcohol withdrawal? Now that we better understand how alcohol consumption and withdrawal are linked to seizures, let’s map out the steps we can take to prevent them and maintain our well-being. While consuming alcohol can lead to seizures, the more common alcohol-related reason for seizures is alcohol withdrawal. Alcohol is directly linked to an increased seizure risk due to the way alcohol affects our brain chemistry.

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